Saccharomyces boulardii CNCM I-745 supplementation during and after antibiotic treatment positively influences the bacterial gut microbiota

Introduction Antibiotic effects on gut bacteria have been widely studied, but very little is known about the consequences of such treatments mycobiota, fungal part microbiota and how length administration influences both microbiota. Here, we examined effect antibiotics (ATB) composition bacterial Saccharomyces boulardii CNCM I-745 Methods In order to get closer human microbiota, mice used in this study were subjected fecal transfer (FMT) using feces subsequently called microbiotaassociated (HMA) mice. These then treated with amoxicillinclavulanate supplemented S. during after ATB treatment understand yeast probiotic Bacterial analyses done 16S ITS2 rRNA amplicon-based sequencing. Results We showed that had limited populations long term, once has cleared from gut. Concerning allowed a better recovery end period. Additionally, sequence analysis revealed 7 additional days (17 total) enhanced return initial equilibrium. Discussion study, provide comprehensive can influence model broad-spectrum antibiotherapy.